Deno is a runtime for JavaScript and TypeScript made with V8, Rust, and Tokio. Node.js is a cross-platform, JavaScript runtime environment that executes JavaScript code outside a web browser. Node.js can manipulate files on the server, collect data and generate dynamic page content. Deno contains TypeScript compiler. Deno is not part of the Node/npm ecosystem. It is fast. Let’s look at some similarities first.

They both run TypeScript code. Both Deno and Node run on Linux, Mac, and Windows. Uses V8 JavaScript engine. Now let’s look at the differences. In the case of libraries you can use all Node libraries available on npm. In the case of Deno there are 55 third-party modules on deno’s website and 56 on github. Installation of ts-node is by installing Node.js and typescript and ts-node with their dependencies with npm using command npm install typescript ts-node. For installing Deno, download deno single binary from github. Your code can use Node API, built-in Node modules, modules from npm in ts-node. In Deno you can use Deno API, Deno built-in modules, other available Deno modules. In ts-node you can import the dependencies installed with npm whereas in Deno you import URLs directly from the Web.